Doxycycline counteracts neuroinflammation restoring memory in Alzheimer’s disease mouse models

β-amyloid oligomers (AβOs) and neuroinflammation are two main culprits to counteract in Alzheimer’s disease (AD). Doxycycline (DOXY) is a second generation antibiotic of the tetracycline class which are promising drugs tested in many clinical trials for a number of different pathologies. DOXY is endowed with anti-amyloidogenic properties and better crosses the blood-brain barrier, but its efficacy has never been tested in AD mice. We herein show that 15-16 months old APP/PS1dE9 (APP/PS1) AD mice receiving DOXY under different treatment regimens recovered their memory without plaque reduction.📍

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