Aβ dimers induce behavioral and neurochemical deficits of relevance to early Alzheimer’s disease


We examined behaviors and neurotransmitter levels in the tgDimer mouse, a model for early Alzheimer’s disease, that expresses exclusively soluble amyloid-beta ‘’Aβ’’ dimers, and is devoid of Aβ plaques, astrogliosis and neuroinflammation. Seven-month old mice were subjected to tests of motor activity, attention, anxiety, habituation learning, working memory and depression-related behaviors. They were impaired in non-selective attention and motor learning and showed anxiety- and despair-related behaviors.📍

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